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Infectious Disease Alert Updates
Mandating COVID-19 Vaccination for Healthcare Workers — Revisited; SARS-CoV-2 as a North American Zoonosis; VIRSTA vs. PREDICT in Predicting Endocarditis
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Herpes Simplex Virus 2 Meningitis in Adults
The incidence of herpes simplex virus 2 meningitis in adults in Denmark over a six-year period was 0.7/100,000 population per year, with 91% of cases occurring in the absence of immunocompromise. Neurocognitive or neuropsychiatric symptoms persisted for as long as six months in approximately one-fifth of cases.
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Optimism for New Interventions to Prevent Respiratory Syncytial Virus Infections
Previous vaccines for respiratory syncytial virus infection in children caused more harm than good. However, new vaccines and preventive monoclonal antibody treatments are nearing final stages of prelicensure testing.
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Successful Post-Discharge Completion of Fidaxomicin Therapy Without Financial Toxicity
Post-discharge completion of fidaxomicin therapy was achieved for most patients with multidisciplinary proactive intervention.
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Active Cancer and Staphylococcus aureus Bacteremia Is Associated with Less Risk for Infective Endocarditis
A multicenter cohort study found patients with S. aureus bacteremia (SAB) and active cancer were at a lower risk for infective endocarditis (IE) than those with SAB without cancer. Persistent bacteremia and cardiomyopathy were independent risk factors for IE.
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COVID-19 Vaccination Prevents Systemic Inflammatory Syndrome (MIS-C)
The estimated effectiveness of two doses of Pfizer-BioNTech vaccine in the prevention of multisystem inflammatory syndrome in children was 91%.
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COVID-19 Vaccination Is Life-Saving
This study confirms the effectiveness of COVID-19 vaccination in preventing severe outcomes between the end of 2020 and October 2021 (i.e., pre-omicron). Age, immunosuppression, and chronic disease were independent risk factors. In contrast to previous studies largely involving unvaccinated individuals, male sex and race/ethnicity were not.
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Vaccines Saved 1 Million Lives in 2021
COVID-19 vaccines prevented an estimated 1 million deaths and 10 million hospitalizations in the United States in 2021, according to a new modeling study by the Commonwealth Fund.
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The Ethical and Pandemic Problem with Boosters
COVID-19 booster shots are highly controversial from a global perspective. Similar to other industrialized nations, 75% of the people in United States have taken at least one dose, 63% are fully vaccinated, and 25% have received the booster. Yet, more than 30 countries worldwide have vaccinated less than 10% of their population.
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Sick Healthcare Workers Worsen Shortage, May Spike Healthcare-Associated Infections
The COVID-19 omicron variant, known to cause breakthrough infections in those fully vaccinated and boosted, is infecting and furloughing healthcare workers even as hospitals face a towering wave of incoming patients.